Basic Information
VIS ID
TVIS44005653
Fusion event
HTLV-1-C5orf30 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
q21.1
Reference genome
GRCh37/hg19
Start
102610203/103274502 (Hg38)
End
102610203/103274502 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA5F
Target gene
C5orf30
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-98-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-194-3p ; hsa-mir-3977 ; hsa-mir-526b-5p ; hsa-mir-4276 ; hsa-mir-4635 ; hsa-mir-5693 ; hsa-mir-520f-3p ; hsa-mir-302c-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-520c-3p ; hsa-mir-520b ; hsa-mir-520a-3p ; hsa-mir-373-3p ; hsa-mir-372-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302b-3p ; hsa-mir-302a-3p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p
Nearest miRNA
hsa-mir-10397/Upstream/2457937; hsa-mir-103a-1/Downstream/7239327;
Nearest TSS
ENST00000502646/Upstream/15078; ENST00000514769/Downstream/138009;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/14653, chr5-CpG: 253/Downstream/4394927
Upstream sequence
aGCTGATTACTTTAAATCTAAAAGGGTTCAGGGACTAGAGTATTTTGGTGAAATAAAAATGGCAAATAGTCTAAGGTTGAGAATAAATAGTGAGTAATAC
Downstream sequence
TATATAGATCCTTTGGCATTTGCTTTATCTCAAATATTGTAATAAATGTTTGTTTTCAGTGGGGATCATAGGAAGGACAGCGTGGTATCTGGTAACTTCA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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