Basic Information
VIS ID
TVIS44005675
Fusion event
HTLV-1-ARHGAP21 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24907981/24619052 (Hg38)
End
24907981/24619052 (Hg38)
Orient
-
Location type
Intronic
Target gene
ARHGAP21
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-21-5p ; hsa-mir-361-3p ; hsa-mir-183-5p ; hsa-mir-4659b-3p ; hsa-mir-4659a-3p ; hsa-mir-4677-5p ; hsa-mir-190a-3p ; hsa-mir-22-5p ; hsa-mir-2116-5p ; hsa-mir-3182 ; hsa-mir-5011-5p ; hsa-mir-1277-5p
Nearest miRNA
hsa-mir-1265/Upstream/343271; hsa-mir-107/Downstream/3670206;
Nearest TSS
ENST00000439456/Upstream/11174; ENST00000610158/Downstream/2317;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/923003, chr10-CpG: 209/Downstream/103616
Upstream sequence
TGGCACACGCTTATAATTTAAGTAACTTCTCTAAATCTGTTCCAGGATTTATAGTATGGCAAACTAACTTGACAATGAAGAGGTCTTTTCTCTCAGTACA
Downstream sequence
CGTTAAATTTACAAAGAAATATGTTTTAGAAAGTAAAAGCACTGTTTAAATGAAAGGTTGGTAACTAATTATCAAAACTGTTCCACTTGGTTTTTCATTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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