Basic Information
VIS ID
TVIS44005691
Fusion event
HTLV-1-RYR1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr19
Cytoband
q13.2
Reference genome
GRCh37/hg19
Start
38935192/38444552 (Hg38)
End
38935192/38444552 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA19A
Target gene
RYR1
Nearest miRNA
hsa-mir-10395/Upstream/3098925; hsa-let-7e/Downstream/965071;
Nearest TSS
ENST00000633603/Upstream/10722; ENST00000594111/Downstream/21576;
Nearest CpG islands
None/Target, chr19-CpG: 112/Upstream/25952, chr19-CpG: 30/Downstream/8189
Upstream sequence
TGTGATCTCTGATGACTCTGTCTCCCATCTGCCGGTTTCCGGGTATCCACCCTTGATTTCTGGCCTCTGACGCTGGGACTCTCGCCCACCCCTGCAATCG
Downstream sequence
TCTCTGACTGCCGCATCCTGGTGGCCCCCAGCACCTGTCGACCGCCAGTGGGGAGCTCCAGGTTGACGCTTCCTTCATGCAGACACTATGGAACATGAAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate