Basic Information
VIS ID
TVIS44005732
Fusion event
HTLV-1-ZNF18 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr17
Cytoband
p12
Reference genome
GRCh37/hg19
Start
11916503/12013186 (Hg38)
End
11916503/12013186 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA17A
Target gene
ZNF18
miRNAs that regulate target gene
hsa-mir-335-3p ; hsa-mir-3616-5p ; hsa-mir-425-5p ; hsa-mir-4670-3p ; hsa-mir-5096 ; hsa-mir-5195-5p ; hsa-mir-573 ; hsa-mir-6802-3p
Nearest miRNA
hsa-mir-1253/Upstream/3826182; hsa-mir-10226/Downstream/68713;
Nearest TSS
ENST00000595228/Upstream/15676; ENST00000582897/Downstream/7638;
Nearest CpG islands
None/Target, chr17-CpG: 26/Upstream/15519, chr17-CpG: 98/Downstream/7448
Nearby gene
MAP2K4(+7632) ;
Upstream sequence
gactacaggcatgtgccaccatgcccggctaatttttgtgtttttagtagaaatggggtttcaccgtgttagctgggagggtctccatctcttgacatcg
Downstream sequence
tgatccacccacctgcgcctcccaaagtgctgggattacaggcgtgagccactgtgcctggccaatttataggaaatttttattagtgaaattaatcctt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate