Basic Information
VIS ID
TVIS44005737
Fusion event
HTLV-1-CDH23 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q22.1
Reference genome
GRCh37/hg19
Start
73564840/71805083 (Hg38)
End
73564840/71805083 (Hg38)
Orient
+
Location type
Intronic
Target gene
CDH23
Nearest miRNA
hsa-mir-1265/Upstream/14283; hsa-mir-107/Downstream/915946;
Nearest TSS
ENST00000439456/Upstream/8227; ENST00000441348/Downstream/14188;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/31348, chr10-CpG: 41/Downstream/45821
Upstream sequence
atgtattaattatctatatgtcgtcctacttgttattaattagacgtaactgccatttagaactttcagttgtcatgatccatgagataaacaatgaaac
Downstream sequence
catgctgagctgatcatttttcaactaaaagcaaagaaacgtgccctttctttttccctgggcagccttgtcatgggtcaatgtatgatttcaatgaggt
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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