Basic Information
VIS ID
TVIS44005751
Fusion event
HTLV-1-C12orf54 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q13.11
Reference genome
GRCh37/hg19
Start
48861534/48467751 (Hg38)
End
48861534/48467751 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA12A
Target gene
C12orf54
Nearest miRNA
hsa-mir-1244-3/Upstream/334884; hsa-let-7i/Downstream/186693;
Nearest TSS
ENST00000382841/Upstream/106831; ENST00000266594/Downstream/4914;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/116435, chr12-CpG: 34/Downstream/60240
Nearby gene
ANP32D(+4914) ;
Upstream sequence
cagagagggctaagatgacagattaccaaggggcccaaggaaacttttgaattcatggatattttcattatcttgtttctgttgataatttcatgggtgt
Downstream sequence
atacgcatgcccaaaattaacaagtatgtgtcttttattgcatgtcaattatacctcaataaagttCTTGAAAATATAGTCTAAATTTAGTCTTTTGTTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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