Basic Information
VIS ID
TVIS44005792
Fusion event
HTLV-1-ABLIM2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
7983551/7981824 (Hg38)
End
7983551/7981824 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
ABLIM2
Nearest miRNA
hsa-mir-378d-1/Upstream/521706; hsa-mir-12113/Downstream/23477;
Nearest TSS
ENST00000502981/Upstream/41898; ENST00000608962/Downstream/1608;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/41698, chr4-CpG: 22/Downstream/103618
Upstream sequence
ctattttccaggccctgggcaaagggctttatgcagcctctcgtctgcagagcagcttggtcaaatggaatcaatatcctcatcttagaggtgcagaaac
Downstream sequence
cacagctcaagagcacccagccagctagtgcagggcagtgggtgcgtgctcagTGTTCCTGGTAAGGACGTACTTCCTATCTGGGGACACAGCCTGTAGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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