Basic Information
VIS ID
TVIS44005795
Fusion event
HTLV-1-FRYL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p11
Reference genome
GRCh37/hg19
Start
48648812/48646795 (Hg38)
End
48648812/48646795 (Hg38)
Orient
+
Location type
Intronic
Target gene
FRYL
miRNAs that regulate target gene
hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15a-5p ; hsa-mir-15b-5p ; hsa-mir-1261 ; hsa-mir-128-3p ; hsa-mir-216a-3p ; hsa-mir-224-5p ; hsa-mir-27a-3p ; hsa-mir-27b-3p ; hsa-mir-3171 ; hsa-mir-3681-3p ; hsa-mir-3681-5p ; hsa-mir-376b-5p ; hsa-mir-376c-5p ; hsa-mir-6849-5p
Nearest miRNA
hsa-mir-12113/Upstream/994052; hsa-mir-1243/Downstream/4065887;
Nearest TSS
ENST00000502981/Upstream/12385; ENST00000511662/Downstream/7122;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/155223, chr4-CpG: 121/Downstream/132519
Upstream sequence
ACAATAGGCAAGACAGCTGTCAGGTATCATATTTAAAATATTAAGCAGTCAGTACAGAGGGGCTATCAGAAGAGCTACAGCCAGGATGCCTAATGACTGA
Downstream sequence
ATACCAGCATTGTTGGAGGTCATACGGCATCTAATTATGGAGGCAGAAGATGGTACCTAGAGAATATGATAACAGGTAAAAAGCACCAGGGAGGTCCAGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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