Basic Information
VIS ID
TVIS44005805
Fusion event
HTLV-1-CTNND2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr5
Cytoband
p15.2
Reference genome
GRCh37/hg19
Start
11014956/11014844 (Hg38)
End
11014956/11014844 (Hg38)
Orient
+
Location type
Intronic
Target gene
CTNND2
Nearest miRNA
hsa-mir-10397/Upstream/536699; hsa-mir-103a-1/Downstream/3811085;
Nearest TSS
ENST00000502646/Upstream/237782; ENST00000505877/Downstream/3216;
Nearest CpG islands
None/Target, chr5-CpG: 87/Upstream/253031, chr5-CpG: 115/Downstream/369725
Nearest cancer related gene
CTNND2(OG, No orient, 0)
Upstream sequence
TTCTGGCCTCTGTACCTGGGTTCGACAAGAAAATGAGCATGACAGATGGCGCCGAATTCTGTTCCACGGACATGTAACTCTCAATCCAATTCCCATCTCT
Downstream sequence
CCCCTCACACTTTCCCTTTTATCCATAATGTCCTTATCTCTTACCTCCTAATTATGCAAACTCCATAAATGCCTCTCCAGATTTGGTCTATAAGTTTCTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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