Basic Information
VIS ID
TVIS44005808
Fusion event
HTLV-1-PAQR8 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
52257801/52393003 (Hg38)
End
52257801/52393003 (Hg38)
Orient
-
Location type
Intronic
Target gene
PAQR8
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-375 ; hsa-mir-326 ; hsa-mir-557 ; hsa-mir-507 ; hsa-mir-3679-3p ; hsa-mir-6881-3p ; hsa-mir-877-3p ; hsa-mir-361-3p ; hsa-mir-5196-3p ; hsa-mir-129-5p ; hsa-mir-136-5p ; hsa-mir-153-5p ; hsa-mir-192-3p ; hsa-mir-4480 ; hsa-mir-4776-3p ; hsa-mir-7705
Nearest miRNA
hsa-mir-10398/Upstream/243962; hsa-mir-10524/Downstream/883990;
Nearest TSS
ENST00000381078/Upstream/30557; ENST00000635843/Downstream/20011;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/29795, chr6-CpG: 20/Downstream/10180
Upstream sequence
AAGTAAACTCAGTGTCAAAGATCTGAGAAACTTTGCAGTACTGATTGTTTTTGTAAGGCCAACTGCAAGTTATTTTTGTTAATGAAGCAAAGCAGTATTG
Downstream sequence
CAGCAGCATATTTGAAGTTGTATATCAAAAAATATTGGGGTTTAGTCATAGAGGGCATTTTTTGAGgcatagtggttaagaacgcagactttagagtcaa
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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