Basic Information
VIS ID
TVIS44005810
Fusion event
HTLV-1-SH3BGRL2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr6
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
80412826/79703109 (Hg38)
End
80412826/79703109 (Hg38)
Orient
+
Location type
UTR3
Target gene
SH3BGRL2
miRNAs that regulate target gene
hsa-mir-195-5p
Nearest miRNA
hsa-mir-10398/Upstream/1163800; hsa-mir-1202/Downstream/10609633;
Nearest TSS
ENST00000381078/Upstream/71826; ENST00000436418/Downstream/104116;
Nearest CpG islands
None/Target, chr6-CpG: 120/Upstream/165406, chr6-CpG: 84/Downstream/243918
Upstream sequence
GTGGAGGAAGTGATCAGAGGGAACGAGCTGTAGGTTTGCAGAAATGTGTGAAACCAAAATGATCACTGCCTACTTGTGATTCAAATCTTCAGAGTTTTCC
Downstream sequence
TAGTTCTTCTAGAAATACATGTCAGGTTTGTTTGTTCATCCTTTCTGTCAGCATGGATCAAGCCCCTAAAATGTGGTAAGTGTTGTCAGAGCAGGGCAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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