Basic Information
VIS ID
TVIS44005816
Fusion event
HTLV-1-VKORC1L1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.21
Reference genome
GRCh37/hg19
Start
65382950/65917963 (Hg38)
End
65382950/65917963 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
VKORC1L1
miRNAs that regulate target gene
hsa-mir-6882-5p ; hsa-mir-1264 ; hsa-mir-3611 ; hsa-mir-1257 ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6893-3p ; hsa-mir-370-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-4789-5p ; hsa-mir-4766-3p ; hsa-mir-466 ; hsa-mir-656-5p ; hsa-mir-758-5p ; hsa-mir-3908 ; hsa-mir-4703-5p ; hsa-mir-3942-5p ; hsa-mir-4661-5p ; hsa-mir-4789-3p ; hsa-mir-4643 ; hsa-mir-3133 ; hsa-mir-186-5p ; hsa-mir-552-5p ; hsa-mir-4328 ; hsa-mir-6512-5p ; hsa-mir-140-3p ; hsa-mir-4652-3p ; hsa-mir-4743-3p ; hsa-mir-3686 ; hsa-mir-4775 ; hsa-mir-4742-3p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-4735-5p ; hsa-mir-8073 ; hsa-mir-221-5p ; hsa-mir-590-3p ; hsa-mir-3934-5p ; hsa-mir-5095 ; hsa-mir-552-3p ; hsa-mir-6504-3p ; hsa-mir-6807-5p ; hsa-mir-6872-3p ; hsa-mir-7151-3p
Nearest miRNA
hsa-mir-1183/Upstream/1238787; hsa-mir-10399/Downstream/1196359;
Nearest TSS
ENST00000635602/Upstream/44594; ENST00000496336/Downstream/49945;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/43922, chr7-CpG: 66/Downstream/63821
Upstream sequence
taagccaaaactctgtcaagttatatagggtggtggctttgcctaccagggaacatttgacaatggtctggaaatagtcttggtgtcacaactgggcagg
Downstream sequence
gtcgcgataggttagtagtgacatctagcaggtagagtccagggaCAGCTACAGTGACAGTTCTGTCTCGATAGTGCCACTGTTGATGAGCTTTGATACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate