Basic Information
VIS ID
TVIS44005817
Fusion event
HTLV-1-CALN1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q11.22
Reference genome
GRCh37/hg19
Start
71919314/72454329 (Hg38)
End
71919314/72454329 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7J
Target gene
CALN1
miRNAs that regulate target gene
hsa-mir-148b-3p ; hsa-mir-675-5p ; hsa-mir-4635 ; hsa-mir-6849-3p ; hsa-mir-596 ; hsa-mir-634 ; hsa-mir-4520-2-3p ; hsa-mir-3692-3p ; hsa-mir-4520-3p ; hsa-mir-4436b-5p ; hsa-mir-6509-3p ; hsa-mir-3614-5p ; hsa-mir-890 ; hsa-mir-212-3p ; hsa-mir-132-3p ; hsa-mir-6754-3p ; hsa-mir-412-3p ; hsa-mir-6756-3p ; hsa-mir-3127-3p ; hsa-mir-7153-3p ; hsa-mir-137
Nearest miRNA
hsa-mir-1183/Upstream/1146559; hsa-mir-10399/Downstream/243574;
Nearest TSS
ENST00000635602/Upstream/7178; ENST00000434423/Downstream/373845;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/116546, chr7-CpG: 43/Downstream/373604
Nearby gene
CALN1(-41954) ;
Upstream sequence
AGAGGAGCCCCAGGCAGTGCCTGGAGAAGCTGCCCTAGGCTAGGAGGTCTAAGAGATGACTGTGGTGTCTCCACTGGGAGGAGGGAGACCATCAGGGGTG
Downstream sequence
ATGAGACCTGGAGAGCAGGCTTGATCAGGCACCCACCAGACACAGAGAGAGGGGCAGCTGAAAGAGGCCAGCTTCAAGTAATGAACGCCCTGTCCCACTG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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