Basic Information
VIS ID
TVIS44005818
Fusion event
HTLV-1-MAGI2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.11
Reference genome
GRCh37/hg19
Start
78926396/79297080 (Hg38)
End
78926396/79297080 (Hg38)
Orient
+
Location type
Intronic
Target gene
MAGI2
miRNAs that regulate target gene
hsa-mir-655-3p ; hsa-mir-487b-3p ; hsa-mir-134-5p ; hsa-mir-5047 ; hsa-mir-1301-3p ; hsa-mir-3944-5p ; hsa-mir-5690 ; hsa-mir-4660 ; hsa-mir-4704-5p ; hsa-mir-3912-5p ; hsa-mir-487a-3p
Nearest miRNA
hsa-mir-10525/Upstream/3381811; hsa-mir-10399/Downstream/12906935;
Nearest TSS
ENST00000635602/Upstream/157251; ENST00000442586/Downstream/54805;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/1256340, chr7-CpG: 26/Downstream/155169
Upstream sequence
tcacaccataccccataaatatgtacaattatgtgtcagttataaataaagtaaaacaaaaaataacccttaagtatttcattaagttgaaacctcaaga
Downstream sequence
gaacggagtcattcagtcatgccagcaggaagagcaatcaagtttgcacatgtgcaggcaatgacaaattcatacatcacaaccaccacctggcctacag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate