VISDB - VIS Detail

Basic Information

VIS ID

TVIS44005824

Fusion event

HTLV-1-TMEM64 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr8

Cytoband

q21.3

Reference genome

GRCh37/hg19

Start

91656701/90644473 (Hg38)

End

91656701/90644473 (Hg38)

Orient

Location type

Intronic

Target gene

TMEM64

miRNAs that regulate target gene

hsa-mir-186-5p ; hsa-mir-221-3p ; hsa-mir-181a-5p ; hsa-mir-605-5p ; hsa-mir-331-3p ; hsa-mir-320a ; hsa-let-7a-5p ; hsa-mir-7849-3p ; hsa-mir-2054 ; hsa-mir-4529-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-3680-3p ; hsa-mir-7156-3p ; hsa-mir-1273h-3p ; hsa-mir-5704 ; hsa-mir-7151-3p ; hsa-mir-5095 ; hsa-mir-3944-5p ; hsa-mir-4771 ; hsa-mir-3166 ; hsa-mir-323b-3p ; hsa-mir-1295b-3p ; hsa-mir-15a-3p ; hsa-mir-4717-5p ; hsa-mir-4438 ; hsa-mir-4796-3p ; hsa-mir-548ah-5p ; hsa-mir-3609 ; hsa-mir-583 ; hsa-mir-1276 ; hsa-mir-4311 ; hsa-mir-20b-5p ; hsa-mir-526b-3p ; hsa-mir-17-5p ; hsa-mir-106a-5p ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-2113 ; hsa-mir-218-5p ; hsa-mir-5687 ; hsa-mir-4999-5p ; hsa-mir-8068 ; hsa-mir-4718 ; hsa-mir-1537-5p ; hsa-mir-4666a-3p ; hsa-mir-4328 ; hsa-mir-223-3p ; hsa-mir-655-3p ; hsa-mir-374c-5p ; hsa-mir-494-3p ; hsa-mir-3922-5p ; hsa-mir-4753-5p ; hsa-mir-7844-5p ; hsa-mir-19a-3p ; hsa-mir-19b-3p ; hsa-mir-548x-3p ; hsa-mir-548j-3p ; hsa-mir-548aq-3p ; hsa-mir-548am-3p ; hsa-mir-548aj-3p ; hsa-mir-548ah-3p ; hsa-mir-548ae-3p ; hsa-mir-548z ; hsa-mir-548h-3p ; hsa-mir-548d-3p ; hsa-mir-548bb-3p ; hsa-mir-548ac ; hsa-mir-23a-3p ; hsa-mir-23b-3p

Nearest miRNA

hsa-mir-12123/Upstream/10403000; hsa-mir-10400/Downstream/561012;

Nearest TSS

ENST00000518652/Upstream/24403; ENST00000519233/Downstream/1039;

Nearest CpG islands

None/Target, chr8-CpG: 109/Upstream/642435, chr8-CpG: 159/Downstream/688

Upstream sequence

GAGATGCACACTAGCTATAGAAACCTGAGTAAGCAAAACATATGAATACAAGGACAGAAAAGAGTCTATAATGGTGCAGATACAGAAGAAAAATATATGC

Downstream sequence

TAACTGAGCAAAAGATTATCTGTTCTGTTTTATTCACCACCCCGTGATTTCGAAATGAAGTTCCTCCAAAGAAAGAAAGATAAACAGTAGGATTTTCTTC

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.