Basic Information
VIS ID
TVIS44005834
Fusion event
HTLV-1-AMOT integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chrX
Cytoband
q23
Reference genome
GRCh37/hg19
Start
112063370/112820142 (Hg38)
End
112063370/112820142 (Hg38)
Orient
-
Location type
Intronic
Target gene
AMOT
miRNAs that regulate target gene
hsa-mir-340-5p ; hsa-mir-221-3p ; hsa-mir-16-5p ; hsa-mir-6806-3p ; hsa-mir-3928-5p ; hsa-mir-616-5p ; hsa-mir-373-5p ; hsa-mir-371b-5p ; hsa-mir-7157-5p ; hsa-mir-4310 ; hsa-mir-500a-5p ; hsa-mir-651-3p ; hsa-mir-548e-5p ; hsa-mir-6838-5p ; hsa-mir-497-5p ; hsa-mir-195-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-424-5p ; hsa-mir-103a-3p ; hsa-mir-107 ; hsa-mir-205-5p ; hsa-mir-127-5p
Nearest miRNA
hsa-let-7f-2/Upstream/39354; hsa-mir-105-1/Downstream/1819293;
Nearest TSS
ENST00000429181/Upstream/140088; ENST00000371951/Downstream/2394;
Nearest CpG islands
None/Target, chrX-CpG: 62/Upstream/439328, chrX-CpG: 25/Downstream/20194
Upstream sequence
CCAGTAATTTGTCAATAGGTGCCACTCCCTCATGTAGGGCCCTGCAACAATTTTACGGCCAGTATTTGCCTGATGCAGACCCAAATTTCATATGGAGCAT
Downstream sequence
CCTCCCACTAGGGCCATTTTAGGTTTGCTTATTCATCAAGCATTATCAAGCACTCTGCTCCTTTCCCATAGAGAAAAACCTGTTACAGCAAAACTGTGTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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