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VISDB
Viral Integration Site DataBase
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TVIS44005844
Basic Information
VIS ID
TVIS44005844
Fusion event
HTLV-1-MED17 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q21
Reference genome
GRCh37/hg19
Start
93536394/93803228 (Hg38)
End
93536394/93803228 (Hg38)
Orient
-
Location type
Intronic
Target gene
MED17
miRNAs that regulate target gene
hsa-mir-185-5p
;
hsa-mir-17-5p
;
hsa-mir-20a-5p
;
hsa-mir-93-5p
;
hsa-mir-106a-5p
;
hsa-mir-142-5p
;
hsa-mir-106b-5p
;
hsa-mir-302a-3p
;
hsa-mir-302b-3p
;
hsa-mir-302c-3p
;
hsa-mir-302d-3p
;
hsa-mir-372-3p
;
hsa-mir-373-3p
;
hsa-mir-340-5p
;
hsa-mir-20b-5p
;
hsa-mir-488-3p
;
hsa-mir-520e
;
hsa-mir-520a-3p
;
hsa-mir-526b-3p
;
hsa-mir-520b
;
hsa-mir-520c-3p
;
hsa-mir-519d-3p
;
hsa-mir-520d-3p
;
hsa-mir-616-3p
;
hsa-mir-302e
;
hsa-mir-3609
;
hsa-mir-548ah-5p
;
hsa-mir-4729
;
hsa-mir-5590-3p
;
hsa-mir-5696
;
hsa-mir-6500-3p
;
hsa-mir-510-3p
;
hsa-mir-5692a
;
hsa-mir-4796-3p
;
hsa-mir-6862-5p
;
hsa-mir-4253
;
hsa-mir-3945
;
hsa-mir-5787
;
hsa-mir-4505
;
hsa-mir-24-3p
;
hsa-mir-4284
;
hsa-mir-3622b-5p
;
hsa-mir-6860
;
hsa-mir-612
;
hsa-mir-5189-5p
;
hsa-mir-3187-5p
;
hsa-mir-1285-3p
;
hsa-mir-4478
;
hsa-mir-4419b
;
hsa-mir-3929
;
hsa-mir-500a-5p
;
hsa-mir-512-3p
;
hsa-mir-6499-3p
;
hsa-mir-6807-5p
;
hsa-mir-1273e
;
hsa-mir-1273g-3p
;
hsa-mir-1827
;
hsa-mir-1910-3p
;
hsa-mir-2467-3p
;
hsa-mir-3612
;
hsa-mir-377-5p
;
hsa-mir-4257
;
hsa-mir-4459
;
hsa-mir-455-3p
;
hsa-mir-4695-5p
;
hsa-mir-6086
;
hsa-mir-650
;
hsa-mir-6511a-5p
;
hsa-mir-6516-5p
;
hsa-mir-665
;
hsa-mir-6840-3p
Nearest miRNA
hsa-mir-10392/Upstream/69464; hsa-let-7a-2/Downstream/663267;
Nearest TSS
ENST00000527297/Upstream/1679;
ENST00000638270/Downstream/2873;
Nearest CpG islands
None/Target,
chr11-CpG: 30/Upstream/18264
,
chr11-CpG: 49/Downstream/46893
Upstream sequence
actacGATACCCTTAGTTGCTTTATTTCAGCAGACGTAACTAGCCACAGTAAAGCAAAGCATACTGTGAAACACAAAATAACGACCCTTAGGAGTAGGGG
Downstream sequence
CAGAAAAATACATTTATAATGCTATTGTTTTCTTTCTTTTTGATTTTTCCTATGTACAGTCATTTCCAATATAATACTATTTTTAATGCAGAGGTTTTAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Sample Information
×
Sample name
ATL188
Sample type
Nontumor
Gender
Female
CpG Island Information
×
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