Basic Information
VIS ID
TVIS44005848
Fusion event
HTLV-1-chr16 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q21
Reference genome
GRCh37/hg19
Start
66098037/66064134 (Hg38)
End
66098037/66064134 (Hg38)
Orient
+
Location type
Intergenic
Nearest miRNA
hsa-mir-1225/Upstream/8291782; hsa-mir-11401/Downstream/1138187;
Nearest TSS
ENST00000527434/Upstream/200350; ENST00000568023/Downstream/302488;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/940373, chr16-CpG: 40/Downstream/206248
Nearby gene
CDH5(+302473) ;
Nearest cancer related gene
CDH5(TSG, +302473) ;
Upstream sequence
GGCAGAACCGGGATTAGAGACATACAAGGAAACCATTCCCCAACATGGCAAAAAGTGCCAAATAGCAAATATATTAACTCGGGTGTAATTCTTCAAAATG
Downstream sequence
AGAAATTCTTAATAATCTACAATATGCCTAACACGGTGGTAAGAAAATTTAAAACTCTAATGTAGCAAGACATATAAATTGTGATAAATATCTCTGTCAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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