Basic Information
VIS ID
TVIS44005859
Fusion event
HTLV-1-TADA2B integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
7054118/7052391 (Hg38)
End
7054118/7052391 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
TADA2B
miRNAs that regulate target gene
hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-6124 ; hsa-mir-511-3p ; hsa-mir-651-3p ; hsa-mir-1265 ; hsa-mir-2392 ; hsa-mir-4645-3p ; hsa-mir-4764-5p ; hsa-mir-155-5p ; hsa-mir-124-3p ; hsa-mir-548an ; hsa-mir-5582-5p ; hsa-mir-20a-5p ; hsa-mir-106b-5p ; hsa-mir-7845-5p ; hsa-mir-224-5p ; hsa-mir-4475 ; hsa-mir-519d-3p ; hsa-mir-93-5p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-378d-1/Upstream/1129063; hsa-mir-12113/Downstream/258059;
Nearest TSS
ENST00000502981/Upstream/6160; ENST00000510704/Downstream/433;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/1505, chr4-CpG: 44/Downstream/1902
Upstream sequence
GCACCCCAGGATGTTCACCCAGGGTTTCCACCCAACATGACCCTTTCCTTCCTAAAGGGCGGGCGTTAGGGACTGTTGTTCCGTTAGGTAGACACGGCCT
Downstream sequence
GTAGTTATCTGTTTCAGAGGCCATTGCGGTTCCTGGGGCTCCCTGGCCCCAAGGTTGTCGGGGAAGAGCATGAGTTCCTGGTGGCGTCTGCCCCGGCTGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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