Basic Information
VIS ID
TVIS44005868
Fusion event
HTLV-1-CDH20 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.33
Reference genome
GRCh37/hg19
Start
59104350/61437117 (Hg38)
End
59104350/61437117 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
CDH20
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-148b-3p
Nearest miRNA
hsa-mir-1-2/Upstream/2985959; hsa-mir-5011/Downstream/5644467;
Nearest TSS
ENST00000575820/Upstream/102844; ENST00000587582/Downstream/53425;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/102658, chr18-CpG: 64/Downstream/117101
Nearby gene
CDH20(+53425) ;
Upstream sequence
gaactattcctggaacatagtaggcactcaatgaataatggttGaatgaatgtacttagcacagtgtcctgcacttggtaattgttcaacaGTCACAGTT
Downstream sequence
AATATTCAATACACTCAAGCAGTAAAGAATAATGTGCGGCAAGGGCAAACATTCCATTGCCACCATCAGCCTTTGACCAGAACAAAACATAAATGGCAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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