Basic Information
VIS ID
TVIS44005874
Fusion event
HTLV-1-SVIL integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p11.23
Reference genome
GRCh37/hg19
Start
29825881/29536952 (Hg38)
End
29825881/29536952 (Hg38)
Orient
+
Location type
Intronic
Target gene
SVIL
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-615-3p ; hsa-mir-18a-3p ; hsa-let-7e-5p
Nearest miRNA
hsa-mir-1265/Upstream/1247602; hsa-mir-107/Downstream/8052;
Nearest TSS
ENST00000439456/Upstream/14384; ENST00000375322/Downstream/98020;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/126837, chr10-CpG: 234/Downstream/198191
Upstream sequence
gtgagccgagatcatgccactgcactccagcccgggcgataacagcacgactctgtcacaaaaaaaaaaaaaaaaaaaagaaCGGAGTCTATTATAGTCA
Downstream sequence
CACTCTGCCCACAAATACCAGGCAATTCTCTTGTAAGCAGCTGACTAAAAGTAAAAGGTAATTTAATTTCCATAAGTTTTGCAGTGGCACGTTGGTAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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