Basic Information
VIS ID
TVIS44005875
Fusion event
HTLV-1-SLF2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q24.31
Reference genome
GRCh37/hg19
Start
102669490/100909733 (Hg38)
End
102669490/100909733 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10A ; FRA10B
Target gene
SLF2
miRNAs that regulate target gene
hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-let-7b-5p
Nearest miRNA
hsa-mir-107/Upstream/1985165; hsa-mir-1307/Downstream/65252;
Nearest TSS
ENST00000439456/Upstream/160883; ENST00000609386/Downstream/2836;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/79088, chr10-CpG: 71/Downstream/2877
Nearby gene
SLF2(No orient, 2836)
Upstream sequence
CATCCTTTTGCACAGTGATTTGTGTGGATCTTGAGATGCTGTGAGCTTGCCATCCCTTCTTGAGATCATCACGTGGTCTGTCTTTCTCTGTCAGGCTTTC
Downstream sequence
AAGTTAATTATTTCCTGTTTTTCTGAGTCTGTTCCTTATCCCCCTTCCCAGGCCACCCTCTACCCTCACCTTCACCTCCCCCCAGCAGTTCTACAGAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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