Basic Information
VIS ID
TVIS44005883
Fusion event
HTLV-1-EXOC5 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr14
Cytoband
q22.3
Reference genome
GRCh37/hg19
Start
57698840/57232122 (Hg38)
End
57698840/57232122 (Hg38)
Orient
+
Location type
Intronic
Target gene
EXOC5
miRNAs that regulate target gene
hsa-mir-590-3p ; hsa-mir-132-3p ; hsa-mir-103a-3p ; hsa-mir-32-5p ; hsa-mir-21-5p ; hsa-mir-877-3p ; hsa-mir-484 ; hsa-mir-548c-3p ; hsa-mir-3613-3p ; hsa-mir-607 ; hsa-mir-153-5p ; hsa-mir-4480 ; hsa-mir-656-3p ; hsa-mir-5586-3p ; hsa-mir-186-5p ; hsa-mir-3133 ; hsa-mir-3668 ; hsa-mir-4773 ; hsa-mir-34a-3p ; hsa-mir-548e-5p ; hsa-mir-371a-5p ; hsa-mir-888-5p ; hsa-mir-25-3p ; hsa-mir-363-3p ; hsa-mir-367-3p ; hsa-mir-92a-3p ; hsa-mir-92b-3p ; hsa-mir-651-5p ; hsa-mir-4756-3p ; hsa-mir-3919 ; hsa-mir-6502-3p ; hsa-mir-4446-5p ; hsa-mir-5006-3p ; hsa-mir-4755-5p ; hsa-mir-642a-5p ; hsa-mir-642b-3p ; hsa-mir-642a-3p ; hsa-mir-4753-3p ; hsa-mir-130b-5p ; hsa-mir-4698 ; hsa-mir-8063 ; hsa-mir-5586-5p ; hsa-mir-216b-5p ; hsa-mir-551b-5p
Nearest miRNA
hsa-mir-208a/Upstream/2353929; hsa-mir-1185-1/Downstream/2414840;
Nearest TSS
ENST00000550708/Upstream/119462; ENST00000554213/Downstream/250;
Nearest CpG islands
None/Target, chr14-CpG: 35/Upstream/414282, chr14-CpG: 57/Downstream/36266
Upstream sequence
TTCATCACATGGGACCCAAAACAGAGTACTGAAAGATCTACTGTCTGTTCACCCTCTTTTGTTTTGTCCTTGTGGACTTTCCCTCTAATTTTCTATTTCC
Downstream sequence
CATTGCTGAAGATAGGGTCATAACAGTGTTGTTGTTGAGATGGACTTCCTCATTACGGTAACTTTGGAAAAACCTTCTCCCAAAATGAAGACACTGAAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate