Basic Information
VIS ID
TVIS44005892
Fusion event
HTLV-1-CRMP1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.2
Reference genome
GRCh37/hg19
Start
5863788/5862061 (Hg38)
End
5863788/5862061 (Hg38)
Orient
-
Location type
Intronic
Target gene
CRMP1
miRNAs that regulate target gene
hsa-mir-7109-5p ; hsa-mir-7111-5p ; hsa-mir-6870-5p ; hsa-mir-5698 ; hsa-mir-4723-5p ; hsa-mir-7106-5p ; hsa-mir-6825-5p ; hsa-mir-765 ; hsa-mir-5703 ; hsa-mir-4516 ; hsa-mir-4434 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-151b ; hsa-mir-151a-5p ; hsa-mir-4781-5p ; hsa-mir-187-3p
Nearest miRNA
hsa-mir-4800/Upstream/3611905; hsa-mir-12113/Downstream/61214;
Nearest TSS
ENST00000502981/Upstream/35200; ENST00000507424/Downstream/25752;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/150337, chr4-CpG: 133/Downstream/25415
Upstream sequence
GTGCAGCTCTAGACAGAATCCACAGCCAGGCAGCCAAGACAGCAGCCTCTGCCCTCCTGGGCTCCTGTGAGAAGCTGGGCCAGCAAGCAGGTCCCAGCTG
Downstream sequence
GGGCTCCCCCAAAGAAGTGGGTGCCACACACTGTCCTCTTAACCCAGGAAATAAGCCTAGGACCGCATAGTGCCAGGGACAAGGTGGACACCCAGAAAAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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