Basic Information
VIS ID
TVIS44005913
Fusion event
HTLV-1-CD81 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
p15.5
Reference genome
GRCh37/hg19
Start
2409537/2388307 (Hg38)
End
2409537/2388307 (Hg38)
Orient
-
Location type
Intronic
Target gene
CD81
miRNAs that regulate target gene
hsa-mir-155-5p ; hsa-mir-423-5p ; hsa-mir-769-3p ; hsa-let-7b-5p ; hsa-mir-1260b ; hsa-mir-582-5p ; hsa-mir-1265 ; hsa-mir-6504-3p ; hsa-mir-8070 ; hsa-mir-3937 ; hsa-mir-4672 ; hsa-mir-4789-5p ; hsa-mir-6768-5p ; hsa-mir-3152-3p ; hsa-mir-5702 ; hsa-mir-6126 ; hsa-mir-6864-5p ; hsa-mir-4493 ; hsa-mir-605-3p ; hsa-mir-552-3p ; hsa-mir-8080 ; hsa-mir-101-3p ; hsa-mir-190a-3p
Nearest miRNA
hsa-mir-210/Upstream/215169; hsa-let-7a-2/Downstream/1467755;
Nearest TSS
ENST00000527297/Upstream/2221; ENST00000530239/Downstream/1788;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/2610, chr11-CpG: 27/Downstream/8113
Upstream sequence
agcCCCCTCTGGCCTTATTGTTTGCCAGGCCCAGCTCAGGTCCCGGAGGAGGGGAGACAGGAGTGTGAGGGAAAGGGGGAAGAGGTATAGAGCCCCCAGC
Downstream sequence
TCCTCCACCCACCCGAACCCTCACCGAGGCCCTAGACCCTAGACCGGCCTGACCGGGGGGTCCTCAGGCCGGGGACTTGGGTGCAGGCCATGGTGCTGGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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