Basic Information
VIS ID
TVIS44005946
Fusion event
HTLV-1-NEDD4L integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr18
Cytoband
q21.31
Reference genome
GRCh37/hg19
Start
56060503/58393271 (Hg38)
End
56060503/58393271 (Hg38)
Orient
-
Location type
Intronic
Fragile sites / regions
FRA18B
Target gene
NEDD4L
miRNAs that regulate target gene
hsa-mir-24-3p ; hsa-mir-1296-5p ; hsa-mir-423-5p ; hsa-mir-7855-5p ; hsa-mir-6807-5p ; hsa-mir-7843-3p ; hsa-mir-4710 ; hsa-mir-4792 ; hsa-mir-650 ; hsa-mir-3612 ; hsa-mir-2467-3p ; hsa-mir-6086 ; hsa-mir-377-5p ; hsa-mir-1827 ; hsa-mir-4487 ; hsa-mir-558 ; hsa-mir-3160-3p ; hsa-mir-5186 ; hsa-mir-4786-3p ; hsa-mir-665 ; hsa-mir-4459 ; hsa-mir-4257 ; hsa-mir-6511a-5p ; hsa-mir-1910-3p ; hsa-mir-4695-5p ; hsa-mir-3924 ; hsa-mir-190a-3p ; hsa-mir-6504-3p ; hsa-mir-656-3p ; hsa-mir-5011-5p ; hsa-mir-93-3p ; hsa-mir-30a-5p ; hsa-mir-376c-3p
Nearest miRNA
hsa-mir-1-2/Upstream/2913973; hsa-mir-122/Downstream/57803;
Nearest TSS
ENST00000575820/Upstream/3207; ENST00000585470/Downstream/6811;
Nearest CpG islands
None/Target, chr18-CpG: 67/Upstream/136435, chr18-CpG: 92/Downstream/277708
Nearest cancer related gene
NEDD4L(TSG, No orient, 0)
Upstream sequence
CACATATCTTACTATTGAACTGTCTTTTTTATTTCGGAGCCCACATGATTCTGCCACAAGTAGAACTTCCCAGATAAGACCTCTGAACTcagtggttctc
Downstream sequence
aacctcagctgcatgttggaaccatctagagagccttaaagaaatcactgatgcctggaatttggacttcattggtctggtgtgtgacccaggcagtggg
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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