Basic Information
VIS ID
TVIS44005967
Fusion event
HTLV-1-UBE2N integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr12
Cytoband
q22
Reference genome
GRCh37/hg19
Start
93828195/93434419 (Hg38)
End
93828195/93434419 (Hg38)
Orient
-
Location type
Intronic
Target gene
UBE2N
miRNAs that regulate target gene
hsa-mir-128-3p ; hsa-mir-221-3p ; hsa-mir-96-5p ; hsa-mir-877-5p ; hsa-mir-744-5p ; hsa-mir-149-5p ; hsa-mir-4268 ; hsa-mir-4723-5p ; hsa-mir-5698 ; hsa-mir-6870-5p ; hsa-mir-7111-5p ; hsa-mir-4665-5p ; hsa-mir-1275 ; hsa-mir-5010-5p ; hsa-mir-4525 ; hsa-mir-5093 ; hsa-mir-2392 ; hsa-mir-6510-5p ; hsa-mir-3646 ; hsa-mir-497-3p ; hsa-mir-548e-5p ; hsa-mir-5197-5p ; hsa-mir-4470 ; hsa-mir-522-3p ; hsa-mir-4694-3p ; hsa-mir-224-3p ; hsa-mir-4727-3p ; hsa-mir-6793-3p ; hsa-mir-6729-3p ; hsa-mir-1296-3p ; hsa-mir-222-3p ; hsa-mir-664a-5p ; hsa-mir-4794 ; hsa-mir-892b ; hsa-mir-548c-3p ; hsa-mir-665 ; hsa-mir-7977 ; hsa-mir-20b-3p ; hsa-mir-3137 ; hsa-mir-3664-3p ; hsa-mir-4267 ; hsa-mir-4433a-3p ; hsa-mir-4459 ; hsa-mir-4768-3p ; hsa-mir-6736-3p ; hsa-mir-2114-5p ; hsa-mir-5588-3p ; hsa-mir-4695-5p ; hsa-mir-21-5p
Nearest miRNA
hsa-let-7i/Upstream/6689270; hsa-mir-1178/Downstream/1127370;
Nearest TSS
ENST00000382841/Upstream/27096; ENST00000548545/Downstream/6837;
Nearest CpG islands
None/Target, chr12-CpG: 104/Upstream/56000, chr12-CpG: 139/Downstream/6740
Upstream sequence
GTCATTAACACGTGTGGAAAAAATTCCAAACTTGAGCAAAGCAAATGCATAACATTTCCAGTCACAGTCATTTAGCACAGTGAATACTAAAGTACTTGAT
Downstream sequence
AATTTGACAAAACTTAATTTCACTTGTGCAGGAGTTGATCAATCTGGACTAAAGGAACTGCTTGACACAGAGGAGCTTAAAAAAGAATACTGAACTGACT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate