Basic Information
VIS ID
TVIS44005978
Fusion event
HTLV-1-IFT140 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p13.3
Reference genome
GRCh37/hg19
Start
1566910/1516909 (Hg38)
End
1566910/1516909 (Hg38)
Orient
+
Location type
Intronic
Target gene
IFT140
miRNAs that regulate target gene
hsa-mir-93-3p ; hsa-mir-6874-5p ; hsa-mir-6500-5p ; hsa-mir-4633-3p ; hsa-mir-6080 ; hsa-mir-558 ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-22-3p
Nearest miRNA
hsa-mir-3176/Upstream/746632; hsa-mir-11401/Downstream/218076;
Nearest TSS
ENST00000527434/Upstream/3930; ENST00000253934/Downstream/3129;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/6716, chr16-CpG: 36/Downstream/7605
Upstream sequence
gaaaaaaggtttaaagtaacaataaTAAAAACTGGTAGAAAAAGTTGACTGGTAGAAAActgacatgaaaaagatggatgggattaccatcagagtgaga
Downstream sequence
cactgcagaaggaaagctggtaaacttgaagcaacagaaatggcaaatccctaaaatgaaaaacagaaaaagtccttgggggagaaaagaagagcatcag
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate