Basic Information
VIS ID
TVIS44005994
Fusion event
HTLV-1-ROBO2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p12.3
Reference genome
GRCh37/hg19
Start
76450628/76401477 (Hg38)
End
76450628/76401477 (Hg38)
Orient
-
Location type
Intronic
Target gene
ROBO2
miRNAs that regulate target gene
hsa-mir-145-5p ; hsa-mir-342-5p ; hsa-mir-514b-3p ; hsa-mir-514a-3p ; hsa-mir-6844 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-8084
Nearest miRNA
hsa-let-7g/Upstream/663114; hsa-mir-12124/Downstream/3106410;
Nearest TSS
ENST00000440867/Upstream/90381; ENST00000471893/Downstream/638409;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/494320, chr3-CpG: 63/Downstream/637870
Nearby gene
ZNF717(-615894) ;
Upstream sequence
aaatcattttccttacttcaatatctagcacatgactgaagtttaaaaggttattgggtaatgaaAATAATTAAATGAATAATCAATTGTAACATGTAAC
Downstream sequence
ATAGATGGGAAGCCTCTTGAAACAGGCTTTTAACAAAGGCAATGAAGGTGATAAAAGATTAAGTAAGGATGAGCAATTAACAACAATAACGGAACCAGTA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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