Basic Information
VIS ID
TVIS44005997
Fusion event
HTLV-1-PIK3CA integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
q26.32
Reference genome
GRCh37/hg19
Start
178899514/179181726 (Hg38)
End
178899514/179181726 (Hg38)
Orient
-
Location type
Intronic
Target gene
PIK3CA
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-148b-3p ; hsa-mir-335-5p ; hsa-mir-17-5p ; hsa-mir-375 ; hsa-mir-1-3p ; hsa-mir-155-5p ; hsa-mir-490-5p ; hsa-mir-203a-3p ; hsa-mir-139-5p ; hsa-mir-373-3p ; hsa-mir-422a ; hsa-mir-19a-3p ; hsa-mir-10b-5p
Nearest miRNA
hsa-let-7g/Upstream/2666575; hsa-mir-1224/Downstream/4705074;
Nearest TSS
ENST00000440867/Upstream/32199; ENST00000462255/Downstream/37825;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/32606, chr3-CpG: 62/Downstream/79434
Nearest cancer related gene
PIK3CA(OG, No orient, 0)
Upstream sequence
GTCAGAAGTTAAATTTCTAACTTCCAATATTGACAGTGGAGATAATTAAACATATTTTCTCTGCCTTTTTTCCTTATGTTCCTCAAAATTAGTATAAGTC
Downstream sequence
TACTAAATCATAGTCACATACACCATAAAGCACCTATCAAAAGAGTATCAGCTAGGTGAAGTTCAAAGATTATATTCTAGTTTTATTTTAACCTTTAAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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