Basic Information
VIS ID
TVIS44005999
Fusion event
HTLV-1-ZFYVE28 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.3
Reference genome
GRCh37/hg19
Start
2419383/2417656 (Hg38)
End
2419383/2417656 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZFYVE28
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-192-5p
Nearest miRNA
hsa-mir-4800/Upstream/167500; hsa-mir-12113/Downstream/3505619;
Nearest TSS
ENST00000502981/Upstream/10991; ENST00000382849/Downstream/953;
Nearest CpG islands
chr4-CpG: 283/Target, None/Upstream, None/Downstream
Upstream sequence
AGGGCCGGGCGGAGGACCTGTCCCGGATTCCAGAGGACGTGGGTGGGGAAGGGACAAGGATAGGGACAAGGGAGGGGACGCGAACTGGGCCGAGGTGTGG
Downstream sequence
GTCAGTCCTGGTTCGGGAAGGGAGGCCGTTGGCAGGGCCATCAGGATCCTCTCTGGACATGGAAGGACGGGTCTGCCCTGGACCCAGGGATTGGGAAATG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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