Basic Information
VIS ID
TVIS44006021
Fusion event
HTLV-1-AP5Z1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
p22.1
Reference genome
GRCh37/hg19
Start
4824931/4785300 (Hg38)
End
4824931/4785300 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA7B
Target gene
AP5Z1
miRNAs that regulate target gene
hsa-mir-551b-3p ; hsa-mir-551a ; hsa-mir-4530 ; hsa-mir-140-3p ; hsa-mir-4691-3p ; hsa-mir-449b-3p ; hsa-mir-527 ; hsa-mir-518a-5p ; hsa-mir-548aw ; hsa-mir-137 ; hsa-mir-92b-3p ; hsa-mir-92a-3p ; hsa-mir-367-3p ; hsa-mir-363-3p ; hsa-mir-32-5p ; hsa-mir-6838-5p ; hsa-mir-25-3p ; hsa-mir-497-5p ; hsa-mir-424-5p ; hsa-mir-195-5p ; hsa-mir-16-5p ; hsa-mir-15b-5p ; hsa-mir-15a-5p ; hsa-mir-451b ; hsa-mir-128-2-5p ; hsa-mir-128-1-5p ; hsa-mir-6825-5p ; hsa-mir-6877-5p ; hsa-mir-6799-5p ; hsa-mir-6787-5p ; hsa-mir-663a ; hsa-mir-1908-5p ; hsa-mir-4743-5p ; hsa-mir-6851-5p ; hsa-mir-3689d ; hsa-mir-744-5p ; hsa-mir-6134 ; hsa-mir-6089
Nearest miRNA
hsa-mir-339/Upstream/2258155; hsa-mir-10399/Downstream/3265;
Nearest TSS
ENST00000635602/Upstream/1977; ENST00000477454/Downstream/1075;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/251, chr7-CpG: 18/Downstream/185
Upstream sequence
GTCAGCCCCAAGTGTTCTTCAGGCTCCACCCCAGCCCCCAGCCCGGCCCTGTCCCACCTGGGCCCCTCGCCTCAGTCCCACTCAAGTCCTCCTGGGGGCC
Downstream sequence
TGTCCCACCCCCCTGCTCCCGGTCCTGCCTGGAGCTTCCAGAGCACAAGCTGCCCCCTCATTGGGCCACTCTAAGGCTGAGACAGAGCCGGCTGACTTTT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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