Basic Information
VIS ID
TVIS44006037
Fusion event
HTLV-1-MAN1C1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p36.11
Reference genome
GRCh37/hg19
Start
26101199/25774708 (Hg38)
End
26101199/25774708 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1A
Target gene
MAN1C1
miRNAs that regulate target gene
hsa-mir-130b-3p ; hsa-mir-93-5p ; hsa-mir-20a-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-3140-3p ; hsa-mir-3663-3p ; hsa-mir-552-3p ; hsa-mir-6885-3p ; hsa-mir-6769b-5p ; hsa-mir-6769a-5p ; hsa-mir-6871-5p ; hsa-mir-1273e ; hsa-mir-146a-5p ; hsa-mir-146b-5p ; hsa-mir-3689d ; hsa-mir-377-5p ; hsa-mir-455-3p ; hsa-mir-6086 ; hsa-mir-6134 ; hsa-mir-6499-3p ; hsa-mir-6516-5p ; hsa-mir-665 ; hsa-mir-6807-5p ; hsa-mir-6840-3p ; hsa-mir-6851-5p ; hsa-mir-6880-5p ; hsa-mir-7153-5p ; hsa-mir-7847-3p
Nearest miRNA
hsa-mir-12136/Upstream/751122; hsa-mir-101-1/Downstream/131654;
Nearest TSS
ENST00000473358/Upstream/2639; ENST00000475314/Downstream/2881;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/3092, chr1-CpG: 35/Downstream/25616
Upstream sequence
cctttaatcctcacaaccaacccaggaatcattactcccattttatagatgagcaaagtgagtcttcattaaagtgaaataacttgcccaaggtcatcta
Downstream sequence
gctcctaaatcgcagagctgagattcaaacccaggcctCTCGCCacgctgggctcactgcctatgggttagccctgctccacaaggaacagcacAAATAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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