Basic Information
VIS ID
TVIS44006039
Fusion event
HTLV-1-GADD45A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
p31.3
Reference genome
GRCh37/hg19
Start
68153005/67687322 (Hg38)
End
68153005/67687322 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA1L
Target gene
GADD45A
miRNAs that regulate target gene
hsa-mir-374a-5p ; hsa-mir-504-5p ; hsa-mir-26b-5p ; hsa-mir-615-3p ; hsa-mir-135b-3p ; hsa-mir-4678 ; hsa-mir-5681b ; hsa-mir-331-5p ; hsa-mir-4282 ; hsa-mir-3613-3p ; hsa-mir-148b-3p ; hsa-mir-607 ; hsa-mir-5701 ; hsa-mir-370-3p ; hsa-mir-34a-5p
Nearest miRNA
hsa-mir-101-1/Upstream/1058805; hsa-mir-11399/Downstream/496196;
Nearest TSS
ENST00000473358/Upstream/1646; ENST00000414904/Downstream/144981;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/735, chr1-CpG: 89/Downstream/145366
Nearest cancer related gene
GADD45A(TSG, No orient, 0)
Upstream sequence
AAAGTACTATTCTGTCTCTTGGAGTATGGTTGATGGCAATTCCAGTTAACTGCTGTGCAGCTCTCATCTCATTGTGCACACAGCATGGAAATCTTTCTCA
Downstream sequence
AAACTGTTTCACTCAGGTCAGGGTAACAAGTTTGGTAGAGCAAACCGGTGAATGATACTCTCATGCAAAACTGAACAGATATGCAAACATATGTATGTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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