Basic Information
VIS ID
TVIS44006049
Fusion event
HTLV-1-ZNF670-ZNF695 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr1
Cytoband
q44
Reference genome
GRCh37/hg19
Start
247207364/247044062 (Hg38)
End
247207364/247044062 (Hg38)
Orient
-
Location type
ncRNA_intronic
Fragile sites / regions
FRA1I
Target gene
ZNF670-ZNF695
Nearest miRNA
hsa-mir-101-1/Upstream/3697807; hsa-mir-3124/Downstream/157905;
Nearest TSS
ENST00000473358/Upstream/35969; ENST00000474792/Downstream/34674;
Nearest CpG islands
None/Target, chr1-CpG: 111/Upstream/35930, chr1-CpG: 55/Downstream/34215
Upstream sequence
AAAACCTGGGTAAACACCGAAAAAGAGAACTTCTTAAGAAGAGTGATTTACAAAAAGATTTCAGAAGACAATGCTCCTCAAACCAATGTGGGTATCTTCT
Downstream sequence
GCCTTCAACCAAGGATCAAATGCTCCAAGAGCCATTTAACAAATACAGCAGAACTATGTATGTGTCTTAATGCTCAAAGTAAATTTTCCTTTGCTTGAGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate