Basic Information
VIS ID
TVIS44006050
Fusion event
HTLV-1-PIP4K2A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
p12.2
Reference genome
GRCh37/hg19
Start
22954017/22665088 (Hg38)
End
22954017/22665088 (Hg38)
Orient
+
Location type
Intronic
Target gene
PIP4K2A
miRNAs that regulate target gene
hsa-mir-425-5p ; hsa-mir-122-5p ; hsa-mir-30b-5p ; hsa-mir-101-3p ; hsa-mir-193b-3p ; hsa-mir-4270 ; hsa-mir-4441 ; hsa-mir-6754-5p ; hsa-mir-4684-3p ; hsa-mir-218-5p ; hsa-mir-106b-5p ; hsa-mir-20a-5p ; hsa-mir-4763-3p ; hsa-mir-4683 ; hsa-mir-1207-5p ; hsa-mir-571 ; hsa-mir-219a-1-3p ; hsa-mir-367-5p ; hsa-mir-1267 ; hsa-mir-6760-5p ; hsa-mir-548al ; hsa-mir-4445-3p ; hsa-mir-5701 ; hsa-mir-501-5p ; hsa-mir-500a-5p ; hsa-mir-4668-3p ; hsa-mir-6894-5p ; hsa-mir-765 ; hsa-mir-7154-3p ; hsa-mir-766-5p ; hsa-mir-548c-3p ; hsa-mir-5687 ; hsa-mir-4801 ; hsa-mir-4731-3p ; hsa-mir-6515-5p ; hsa-mir-4443 ; hsa-mir-93-5p ; hsa-mir-519d-3p ; hsa-mir-20b-5p ; hsa-mir-17-5p
Nearest miRNA
hsa-mir-1265/Upstream/1168447; hsa-mir-107/Downstream/1610597;
Nearest TSS
ENST00000439456/Upstream/55371; ENST00000465729/Downstream/26742;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/186967, chr10-CpG: 91/Downstream/48138
Upstream sequence
taaggaaaaaaacataacattattgtaatagcaatacccaagataaccacaatattttgatttttgtatacatatctttatggatatatttaatacattc
Downstream sequence
atataCAAACACACACACATACATTTTTACATAAATGAAAAACTGGCTCTATGATGTCTGTCTTCATCACTTTACTTTTTTCCCTCTAACCAACCTGTGA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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