Basic Information
VIS ID
TVIS44006057
Fusion event
HTLV-1-chr10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr10
Cytoband
q26.13
Reference genome
GRCh37/hg19
Start
127289465/125600896 (Hg38)
End
127289465/125600896 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA10D ; FRA10F ; FRA10A ; FRA10B
Target gene
LOC102724793 ; TEX36
miRNAs that regulate target gene
hsa-mir-335-5p
Nearest miRNA
hsa-mir-107/Upstream/568026; hsa-mir-202/Downstream/218844;
Nearest TSS
ENST00000439456/Upstream/26451; ENST00000530795/Downstream/82210;
Nearest CpG islands
None/Target, chr10-CpG: 68/Upstream/372139, chr10-CpG: 84/Downstream/118162
Nearby gene
TEX36-AS1(No orient, 22451)
Upstream sequence
ATTAGTGTTTCAAGGGTACATGGAGCCCTGTCTGTGAGAAAGCACAAAGATCTGATTTTGCAACTGTGAGACACTGAATACCGCGGCCCATTTCTATCTG
Downstream sequence
GATCCTACCTGGAACTGCACTAATCCCAATAGCCTCACTGATGACCTTAGCAAGCAAGAGCAATTGCTAAAGAATACAGTGTATTTGCTGAGTCCAAAAG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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