Basic Information
VIS ID
TVIS44006063
Fusion event
HTLV-1-ANO1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr11
Cytoband
q13.3
Reference genome
GRCh37/hg19
Start
69945718/70099612 (Hg38)
End
69945718/70099612 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA11H ; FRA11A
Target gene
ANO1
miRNAs that regulate target gene
hsa-mir-335-5p ; hsa-mir-124-3p ; hsa-mir-381-3p
Nearest miRNA
hsa-mir-10392/Upstream/1016354; hsa-let-7a-2/Downstream/184343;
Nearest TSS
ENST00000527297/Upstream/14190; ENST00000529913/Downstream/3485;
Nearest CpG islands
None/Target, chr11-CpG: 30/Upstream/11509, chr11-CpG: 18/Downstream/56035
Upstream sequence
CAACAAGAAAAGACAGGCTCTCCCACACGTGGGCTGTCTTTTCTCCTGACTCAGAGGTGCCCCATGAAGTCAGTGCTGTTCCTGTGGGTCACCAGGATGG
Downstream sequence
AAGACCTCCACCTCTCCAGCCTCAGTGCCCTCCGTGGCTCCCCAGCACTGAGGAGGTGGCTTCAAGCTTCTTGGCCGAAGGAGTCTGTGCTTGCACAGGC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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