Basic Information
VIS ID
TVIS44006097
Fusion event
HTLV-1-RAB27A integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr15
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
55520197/55227999 (Hg38)
End
55520197/55227999 (Hg38)
Orient
-
Location type
Intronic
Target gene
RAB27A
miRNAs that regulate target gene
hsa-mir-124-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-31-5p ; hsa-mir-582-3p ; hsa-mir-582-5p ; hsa-mir-129-5p ; hsa-mir-8055 ; hsa-mir-6864-3p ; hsa-mir-3672 ; hsa-mir-4279 ; hsa-mir-6780a-3p ; hsa-mir-4524a-3p ; hsa-mir-5007-5p ; hsa-mir-4797-5p ; hsa-mir-4284 ; hsa-mir-6778-3p ; hsa-mir-2276-3p ; hsa-mir-4638-5p ; hsa-mir-1307-3p ; hsa-mir-1304-3p ; hsa-mir-6741-3p ; hsa-mir-1281 ; hsa-mir-4485-5p ; hsa-mir-4726-3p ; hsa-mir-6764-5p ; hsa-mir-1915-3p ; hsa-mir-6840-3p ; hsa-mir-6890-3p ; hsa-mir-122-3p ; hsa-mir-134-5p ; hsa-mir-1273f ; hsa-mir-153-5p ; hsa-mir-193b-5p ; hsa-mir-3170 ; hsa-mir-411-5p ; hsa-mir-6832-5p ; hsa-mir-6855-5p ; hsa-mir-6890-5p
Nearest miRNA
hsa-mir-10393/Upstream/2950799; hsa-mir-11181/Downstream/144941;
Nearest TSS
ENST00000557528/Upstream/30932; ENST00000569909/Downstream/21036;
Nearest CpG islands
None/Target, chr15-CpG: 55/Upstream/30903, chr15-CpG: 88/Downstream/61575
Upstream sequence
ATAGATTCTCTAGGGTTACACTAACATGACCAAACAGGGAAAATATACATTTGAAAGCTGTTATGCAGTCAAGTGGCAGAATTCGAAATGGCTATGAACC
Downstream sequence
AATCATTTAGGAGGTTAAAATCTCTCCAAAATAAAGGTTGACATATATTGCACTGGTGACCACTTTTACCAATGCAGTTGTAGAGTTTTCCATGGCAGAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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