Basic Information
VIS ID
TVIS44006101
Fusion event
HTLV-1-RBBP6 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
p12.1
Reference genome
GRCh37/hg19
Start
24556212/24544891 (Hg38)
End
24556212/24544891 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA16E
Target gene
RBBP6
miRNAs that regulate target gene
hsa-mir-1254 ; hsa-mir-149-5p ; hsa-let-7b-5p ; hsa-mir-323a-5p ; hsa-mir-876-3p ; hsa-mir-4747-3p ; hsa-mir-1295b-3p ; hsa-mir-5692a ; hsa-mir-548c-3p ; hsa-mir-3129-3p ; hsa-mir-5583-5p ; hsa-mir-6793-3p ; hsa-mir-15a-5p ; hsa-mir-16-5p ; hsa-mir-16-2-3p ; hsa-mir-15b-5p ; hsa-mir-195-5p ; hsa-mir-195-3p ; hsa-mir-424-5p ; hsa-mir-497-5p ; hsa-mir-519c-3p ; hsa-mir-519b-3p ; hsa-mir-519a-3p ; hsa-mir-3942-5p ; hsa-mir-3944-5p ; hsa-mir-4703-5p ; hsa-mir-6838-5p ; hsa-mir-7856-5p ; hsa-mir-193a-5p ; hsa-mir-1182 ; hsa-mir-520a-3p ; hsa-mir-372-3p ; hsa-mir-520e ; hsa-mir-520d-3p ; hsa-mir-302b-3p ; hsa-mir-302c-3p ; hsa-mir-520c-3p ; hsa-mir-302e ; hsa-mir-302d-3p ; hsa-mir-302a-3p ; hsa-mir-520b ; hsa-mir-373-3p ; hsa-mir-107 ; hsa-mir-103a-3p
Nearest miRNA
hsa-mir-1225/Upstream/341660; hsa-mir-11401/Downstream/1480346;
Nearest TSS
ENST00000527434/Upstream/4308; ENST00000613729/Downstream/8102;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/4512, chr16-CpG: 97/Downstream/184454
Upstream sequence
tctccctcttggttttcccagaaggtgacatcactgtttatccgatgactgaagccaggaacccagggattcctctggcctgattcctctttcttcttca
Downstream sequence
tttccttcatctcccccatattcggtccatcagcaagctttgtcaatcctacctgcaaacattctgtctttatttctcacatcataacacaggtcgtcat
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate