Basic Information
VIS ID
TVIS44006103
Fusion event
HTLV-1-ZNF23 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr16
Cytoband
q22.2
Reference genome
GRCh37/hg19
Start
71491835/71457932 (Hg38)
End
71491835/71457932 (Hg38)
Orient
+
Location type
Intronic
Target gene
ZNF23
miRNAs that regulate target gene
hsa-mir-26b-5p ; hsa-mir-324-3p ; hsa-mir-6809-3p ; hsa-mir-6833-3p ; hsa-mir-4768-5p ; hsa-mir-6873-3p ; hsa-mir-6845-3p ; hsa-mir-770-5p ; hsa-mir-4712-5p ; hsa-mir-664a-3p ; hsa-mir-4262 ; hsa-mir-181d-5p ; hsa-mir-181c-5p ; hsa-mir-181a-5p ; hsa-mir-181b-5p
Nearest miRNA
hsa-mir-1225/Upstream/1427510; hsa-mir-11401/Downstream/5411004;
Nearest TSS
ENST00000527434/Upstream/1102; ENST00000567341/Downstream/4282;
Nearest CpG islands
None/Target, chr16-CpG: 29/Upstream/15897, chr16-CpG: 41/Downstream/3938
Upstream sequence
ctttgaCTTATTTCTCTTTCTCAACACAAGCATTATCTTCAGTATCACAGCAGGAGAAGCTGGACTGGCTGGGCTGCAGCCCCAGTACACAAGCCTGGGG
Downstream sequence
AGTCAGACCCCAGGGAGGCAGCGCCTGGAGAAGGCAGCTGCCCCCCAGTATCCTGCCCCACTTCCTCAGAGCTCTGAATGTCCTCAAGAATCCTAACACC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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