VISDB - VIS Detail

Basic Information

VIS ID

TVIS44006106

Fusion event

HTLV-1-ZCCHC14 integration

Validated

Detection method

HTS

Data source

download(RID)

Sample type

Nontumor

Disease

Adult T-cell leukemia (ATL)

Quality evaluation

Normal

Reported year

2014

PubMed ID

24735963

Virus Sequence

Virus name

HTLV-1

Reference genome

Not given

Host Sequence

Chromosome

chr16

Cytoband

q24.2

Reference genome

GRCh37/hg19

Start

87489121/87455515 (Hg38)

End

87489121/87455515 (Hg38)

Orient

Location type

Intronic

Target gene

ZCCHC14

miRNAs that regulate target gene

hsa-mir-130b-3p ; hsa-mir-142-3p ; hsa-mir-24-3p ; hsa-mir-19b-3p ; hsa-mir-1180-3p ; hsa-mir-1301-3p ; hsa-mir-744-5p ; hsa-mir-15b-5p ; hsa-mir-93-5p ; hsa-mir-544a ; hsa-mir-5571-5p ; hsa-mir-153-3p ; hsa-mir-448 ; hsa-mir-432-5p ; hsa-mir-377-3p ; hsa-mir-382-5p ; hsa-mir-493-3p ; hsa-mir-218-5p ; hsa-mir-3674 ; hsa-mir-664b-3p ; hsa-mir-579-3p ; hsa-mir-3190-3p ; hsa-mir-6073 ; hsa-mir-4437 ; hsa-mir-6077 ; hsa-mir-7-5p ; hsa-mir-6849-5p ; hsa-mir-3681-5p ; hsa-mir-3158-3p ; hsa-mir-4446-3p ; hsa-mir-5088-5p ; hsa-mir-4662a-3p ; hsa-mir-20a-3p ; hsa-mir-3163 ; hsa-mir-4272 ; hsa-mir-5680 ; hsa-mir-33a-5p ; hsa-mir-33b-5p ; hsa-mir-1224-5p ; hsa-mir-3944-5p ; hsa-mir-107 ; hsa-mir-103a-3p ; hsa-mir-4751 ; hsa-mir-5004-5p ; hsa-mir-5196-3p ; hsa-mir-1283 ; hsa-mir-520d-5p ; hsa-mir-524-5p ; hsa-mir-5589-3p ; hsa-mir-6863 ; hsa-mir-891a-3p

Nearest miRNA

hsa-mir-12128/Upstream/1537099; hsa-mir-11401/Downstream/379077;

Nearest TSS

ENST00000527434/Upstream/22381; ENST00000562466/Downstream/36344;

Nearest CpG islands

None/Target, chr16-CpG: 29/Upstream/40990, chr16-CpG: 20/Downstream/22238

Upstream sequence

aacattaactcagagtagagcctgaaaaggtaaagatgtgtagtgcattccTGTTgcttctcttaaatggggggctcatagagggcgcaaagtcctagcg

Downstream sequence

tcctacagaagctcttctacgatgaagaacttgactcctcctgtgtctctaatcacattttcttcagggaaattgagaaaaccatcactcaaatgattct

Reference

Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.