Basic Information
VIS ID
TVIS44006118
Fusion event
HTLV-1-SNTG2 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p25.3
Reference genome
GRCh37/hg19
Start
1216461/1220775 (Hg38)
End
1216461/1220775 (Hg38)
Orient
+
Location type
Intronic
Target gene
SNTG2
miRNAs that regulate target gene
hsa-mir-146a-5p
Nearest miRNA
hsa-mir-10b/Downstream/4753887;
Nearest TSS
ENST00000437798/Upstream/11646; ENST00000489646/Downstream/26550;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/52641, chr2-CpG: 26/Downstream/41872
Upstream sequence
AATAATCCCATTCCACTTAGATCTCTACAAACACCCAGTTCTCTGGCATGTGTCCTACTCTGATAAGGGCAGGGGCCACGTGTTTAAGATCTGGAGGTCC
Downstream sequence
TTAAGTCTTCTCAGAAGCCAGTGCTGCCTTCAACACCCGGCAGTTCTGGTGGGGGTGTCTTCCGTGGTGCCCAGCCCTGGGCCGCCCCCTCCACGGGCAC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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