Basic Information
VIS ID
TVIS44006127
Fusion event
HTLV-1-DOK1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
p13.1
Reference genome
GRCh37/hg19
Start
74783052/74555925 (Hg38)
End
74783052/74555925 (Hg38)
Orient
-
Location type
Exonic
Fragile sites / regions
FRA2S ; FRA2E
Target gene
DOK1
miRNAs that regulate target gene
hsa-mir-218-5p
Nearest miRNA
hsa-mir-1285-2/Upstream/4302920; hsa-mir-10b/Downstream/534887;
Nearest TSS
ENST00000437798/Upstream/235; ENST00000416236/Downstream/19564;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/367, chr2-CpG: 43/Downstream/92076
Nearest cancer related gene
DOK1(TSG, No orient, 0)
Upstream sequence
AGTCCTCTGGGTCCCCACTGCTGCCCCCGTCCCTCCCCCGCAGCTGTCTAATCGTGTATGCCTTCCAGGATCCCAATTCTGGGTAACGGTGCAGAGGACT
Downstream sequence
GAGGCCGCCGAGCGCTGTGGCCTGCATGGCTCCTACGTGCTGAGGGTGGAGGCTGAAAGGCTGACTCTCCTGACCGTGGGGGCCCAGAGTCAGATACTGG
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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