Basic Information
VIS ID
TVIS44006132
Fusion event
HTLV-1-DPP10 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q14.1
Reference genome
GRCh37/hg19
Start
116259251/115501675 (Hg38)
End
116259251/115501675 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S
Target gene
DPP10
Nearest miRNA
hsa-mir-1285-2/Upstream/1780307; hsa-mir-10b/Downstream/11921862;
Nearest TSS
ENST00000437798/Upstream/60803; ENST00000473362/Downstream/312988;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/338486, chr2-CpG: 48/Downstream/2312861
Upstream sequence
ATGCTCCCTAAGGACATTTATGTCACAACACAGATAATTAAGCAATTTATAAGTCCTAGAGGTGTCTAAATTCGATGTCGGGCAGGGGTTAGGGGAGTGG
Downstream sequence
AAGGTGGCATCAGTTTGCAACCAGTTACCCAAAACTGAGAACAAAAATAGGAATTACCATAATTCCAGATGATTTCAAAGGAGCTTGTTTAATCATTCTC
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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