Basic Information
VIS ID
TVIS44006133
Fusion event
HTLV-1-ZRANB3 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr2
Cytoband
q21.3
Reference genome
GRCh37/hg19
Start
136284822/135527252 (Hg38)
End
136284822/135527252 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA2S ; FRA2F
Target gene
ZRANB3
miRNAs that regulate target gene
hsa-mir-6855-5p ; hsa-mir-5096 ; hsa-mir-3170 ; hsa-mir-4662a-5p ; hsa-mir-193b-5p ; hsa-mir-6890-5p ; hsa-mir-575 ; hsa-mir-4676-5p ; hsa-mir-6858-3p
Nearest miRNA
hsa-mir-1285-2/Upstream/669379; hsa-mir-10b/Downstream/138145;
Nearest TSS
ENST00000437798/Upstream/173624; ENST00000483021/Downstream/3324;
Nearest CpG islands
None/Target, chr2-CpG: 135/Upstream/474564, chr2-CpG: 36/Downstream/4148
Upstream sequence
tggctcagcataaatctcctcatattttacagtttgactctttttgtcgacaatcatctggcacccacacatggggcctcagagaagactcaggGTCACA
Downstream sequence
CTATACATTTAAAAATGGTTAAGATgaccaggcacggtggctcacacctgtaatcccagcactttgggaggtgaggtgggtggatcactcgaggtcagga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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