Basic Information
VIS ID
TVIS44006151
Fusion event
HTLV-1-GRM7 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr3
Cytoband
p26.1
Reference genome
GRCh37/hg19
Start
7689859/7648172 (Hg38)
End
7689859/7648172 (Hg38)
Orient
+
Location type
Intronic
Target gene
GRM7
miRNAs that regulate target gene
hsa-mir-34a-5p ; hsa-mir-34c-5p
Nearest miRNA
hsa-mir-4790/Upstream/2397917; hsa-let-7g/Downstream/2632179;
Nearest TSS
ENST00000440867/Upstream/40275; ENST00000471242/Downstream/45461;
Nearest CpG islands
None/Target, chr3-CpG: 148/Upstream/785218, chr3-CpG: 42/Downstream/853343
Upstream sequence
GATGTAAACCAGGACACAACTTATTTGTGTGGCAGTGACTTCCAGAGCAGTATCTAAAGCTTTCATTCTTCTTTAAGAGTTTTGGGGGCTCCCAAAAAAG
Downstream sequence
ATTCTGAGAAAGAAATGAGTACCCCTTAACTTCTTTCTCTTAATATGGCTATTATTTTAATTAGTGCtataaatagttttttttttatgtttttaaaaga
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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