Basic Information
VIS ID
TVIS44006167
Fusion event
HTLV-1-SLC2A9 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr4
Cytoband
p16.1
Reference genome
GRCh37/hg19
Start
9980026/9978402 (Hg38)
End
9980026/9978402 (Hg38)
Orient
+
Location type
Intronic
Fragile sites / regions
FRA4A
Target gene
SLC2A9
miRNAs that regulate target gene
hsa-mir-5691 ; hsa-mir-6805-3p ; hsa-mir-466 ; hsa-mir-6740-3p ; hsa-mir-4778-3p ; hsa-mir-4643 ; hsa-mir-4789-3p ; hsa-mir-1264 ; hsa-mir-4446-5p ; hsa-mir-3156-3p ; hsa-mir-1260b ; hsa-mir-1260a ; hsa-mir-188-3p ; hsa-mir-1224-3p ; hsa-mir-4307 ; hsa-mir-33a-3p
Nearest miRNA
hsa-mir-378d-1/Upstream/422086; hsa-mir-12113/Downstream/100209;
Nearest TSS
ENST00000502981/Upstream/55588; ENST00000503493/Downstream/28080;
Nearest CpG islands
None/Target, chr4-CpG: 46/Upstream/195066, chr4-CpG: 49/Downstream/40455
Upstream sequence
TAAATAAAGGGTGAAGACAGAGGTTGAAGACAGACCTTACGGACTCAAGCAGGAGAAAGAACTTGATATTGATTTATAAACAAAGTGGAATTTGGAAATG
Downstream sequence
ATCCCCAAAGAGAAAAGTTTAGCTCTACTGAGGTAAATATTTATTTACTTTTTTTACTCCTAAAGGACAATAGCACTCTTCATTGACTTTTAAATGTATT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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