Basic Information
VIS ID
TVIS44006209
Fusion event
HTLV-1-CDK14 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr7
Cytoband
q21.13
Reference genome
GRCh37/hg19
Start
90394588/90765273 (Hg38)
End
90394588/90765273 (Hg38)
Orient
-
Location type
Intronic
Target gene
CDK14
miRNAs that regulate target gene
hsa-mir-1-3p ; hsa-mir-215-5p ; hsa-mir-192-5p ; hsa-mir-26b-5p ; hsa-mir-376c-3p ; hsa-mir-493-5p ; hsa-mir-6780b-5p ; hsa-mir-4725-3p ; hsa-mir-4271 ; hsa-mir-6785-5p ; hsa-mir-6883-5p ; hsa-mir-4728-5p ; hsa-mir-149-3p ; hsa-mir-5196-5p ; hsa-mir-4747-5p ; hsa-mir-6797-5p ; hsa-mir-1249-5p ; hsa-mir-4644 ; hsa-mir-4306 ; hsa-mir-185-5p ; hsa-mir-4533 ; hsa-mir-6133 ; hsa-mir-6130 ; hsa-mir-6129 ; hsa-mir-6127 ; hsa-mir-4510 ; hsa-mir-6783-5p ; hsa-mir-4419a ; hsa-mir-4756-5p ; hsa-mir-4739 ; hsa-mir-1321 ; hsa-mir-6873-5p ; hsa-mir-6856-5p ; hsa-mir-6758-5p ; hsa-mir-4428
Nearest miRNA
hsa-mir-10525/Upstream/14850004; hsa-mir-10399/Downstream/1438742;
Nearest TSS
ENST00000635602/Upstream/38769; ENST00000487145/Downstream/59332;
Nearest CpG islands
None/Target, chr7-CpG: 39/Upstream/168223, chr7-CpG: 255/Downstream/499005
Nearest cancer related gene
CDK14(OG, No orient, 0)
Upstream sequence
GGGAGTCCCAAAGGAAGCCAGATTCCTAATGAGAAAGCAATGGTCTAGGTTAAACAGTGACttttttattaaaaaaagttattttttttttaCTACTTGT
Downstream sequence
TCTTGAGAAAGTTTCATGGCTAAGTGCTGGAGAGTTGAGGGCACCTGGAACTGTGCCCAAAGCAGAGCATAAAGGATTATTAAATTAAAAGAATGTGTAT
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
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