Basic Information
VIS ID
TVIS44006234
Fusion event
HTLV-1-TSC22D1 integration
Validated
No
Detection method
HTS
Data source
download(RID)
Sample type
Nontumor
Disease
Adult T-cell leukemia (ATL)
Quality evaluation
Normal
Reported year
2014
PubMed ID
24735963
Virus Sequence
Virus name
HTLV-1
Reference genome
Not given
Host Sequence
Chromosome
chr13
Cytoband
q14.11
Reference genome
GRCh37/hg19
Start
45085649/44511513 (Hg38)
End
45085649/44511513 (Hg38)
Orient
-
Location type
Intronic
Target gene
TSC22D1
miRNAs that regulate target gene
hsa-mir-100-5p ; hsa-mir-9-3p ; hsa-mir-590-3p ; hsa-mir-6858-5p ; hsa-mir-4689 ; hsa-mir-4784 ; hsa-mir-3150b-3p ; hsa-mir-199b-5p ; hsa-mir-199a-5p ; hsa-mir-1825 ; hsa-mir-708-5p ; hsa-mir-3139 ; hsa-mir-28-5p ; hsa-mir-6758-5p ; hsa-mir-6856-5p
Nearest miRNA
hsa-mir-2276/Upstream/315313; hsa-mir-1267/Downstream/5484902;
Nearest TSS
ENST00000623511/Upstream/37212; ENST00000617014/Downstream/28520;
Nearest CpG islands
None/Target, chr13-CpG: 551/Upstream/74254, chr13-CpG: 216/Downstream/64416
Nearest cancer related gene
TSC22D1(TSG, No orient, 0)
Upstream sequence
TTGGGAAAAGAAAGCTATGAACGTCATAAAACATCCACCCAGCtgtctatcatctcaattaagttgttggtactctaagatcaggagccaagttttattt
Downstream sequence
atcgctaacatctggcatataactaattgacatatagtaattgttcaataTGACAATCCAAAAACACCTATCCATCTAAATGACAGCTTTCTGAATAAAA
Reference
Cook, L. B., et al. The role of HTLV-1 clonality, proviral structure, and genomic integration site in adult T-cell leukemia/lymphoma. Blood,2014, 123(25): 3925-3931.
Curate